wasatch lined: June 2012

Friday, June 29, 2012

TheTonyLee: (2/2) Guthrie doesn't get Int'l issues/ sports like she does law. She'll seem like fish out of water, awkwardness will come across on screen

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Source: http://twitter.com/TheTonyLee/statuses/218692033483784194

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Mr. Issa Goes to Washington

Every politician on Capitol Hill has supporters and haters back home, but Southern California Congressman Darrell Issa is especially revered?and reviled?in his home Congressional District 49.

Seemingly everyone in the 49th, which runs from north San Diego County to central Orange County, has an opinion about Issa, the House Committee on Oversight and Government Reform chair who last week voted with his fellow Republicans on the committee to hold Attorney General Eric Holder in contempt of Congress for not producing subpoenaed documents in the Operation Fast and Furious gun-running sting.

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Mo. Gov. Nixon Signs Small-Business Tax Break ? CBS St. Louis

Missouri Gov. Jay Nixon (UPI/Bill Greenblatt)

JEFFERSON CITY, Mo. (AP)- Gov. Jay Nixon has signed into law a measure offering a tax break for some small businesses in Missouri.

Lawmakers in 2011 approved a tax deduction for small businesses based on each job they add. This year?s measure is designed to clarify the types of businesses that can claim the deduction.

Nixon traveled Wednesday to Kansas City and Joplin for bill signing ceremonies. He says helping small businesses grow and create jobs will help Missouri?s economy.

Last week, Nixon?s administration cited the tax break as one of several measures contributing to a projected state budget shortfall. The governor trimmed $15 million from the budget that takes effect Sunday.

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Thursday, June 28, 2012

SKIN CANCER & PROTANDIM | Diet-Fitness-Health-Healthy Aging

NOTE: Daily Life Source is looking for distributors to help get the word out about Protandim. If you would like a free and no obligation introduction to this business please contact us. We can do the presentation by phone or SKYPE. Dr. Joe McCord explains the Pubmed.gov study on how Protandim affected skin cancer in mice. For more information please visit www.DailyLifeSource.com. * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

www.DermTV.com Connect With DermTV www.facebook.com www.twitter.com In a good portion of DermTV episodes, Dr. Schultz discusses the importance of sun protection. As if you didnapos;t need another reason, in this episode of DermTV, Dr. Schultz actually brings you into the operating room and shows you an actual skin cancer removal. (This video contains a graphic medical procedure. Viewer discretion is advised.) Everyonecan have beautiful, healthy, and younger looking skin, and DermTV, the Internet?s daily skincare video show, will demonstrate how by revealing expert tips and techniques and by providing real solutions for real skincare issues. Skincare (whether cosmetic or medical) previously required a trip to your dermatologist or a shopping spree at the pharmacy. And that?s if you have a trusted nearby dermatologist or a local informed pharmacy. But not anymore. We at DermTV are committed to making best-in-class dermatology and skincare guidance accessible to everyone, anytime, at your computer. Every weekday, our host, Dr. Neal Schultz, one of New York?s most trusted and respected dermatologists (see bio below), teaches skincare?s most timely and timeless issues. Topics include: the best at home techniques and new technology for facial rejuvenation, preventing and fixing sun damage from wrinkles to skin cancer, breaking news in dermatology, general skincare topics, and more.
Video Rating: 4 / 5

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Successful test of interceptor missile off Hawaii

KEKAHA, Hawaii (AP) ? The U.S. military has successfully conducted a test flight of the Navy's newest interceptor missile by shooting down a ballistic missile target off Hawaii.

The Missile Defense Agency says the USS Lake Erie detected and tracked the separating missile launched from Kauai's Pacific Missile Range Facility on Tuesday night.

It's the second consecutive successful intercept test of the SM-3 Block IB missile and the second-generation Aegis Ballistic Missile Defense system, which is operated from ships. The first successful intercept test took place last month.

The agency says the test was the 23rd successful intercept in 28 flight test firings for the Aegis system.

The system is the sea-based midcourse component of the agency's Ballistic Missile Defense System and is designed to intercept and destroy short- to intermediate-range ballistic missile threats.

Associated Press

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'Draw Something' animates John Mayer video

By Randee Dawn

Millions have used "Draw Something" to play a game, but design studio head Jimmy Thompson had a different idea -- he would turn a series of "Draw" sketches into an animated video for?John Mayer's "Queen of California." And Mayer approves.

"A must-see. So great," said the musician, posting on his Tumblr blog.?

The video features some simple and some intricate drawings that help illustrate the song, and it's visually addicting.?

"There is something really charming about the medium -- the strokes -- and I love the anticipation when you watch someone?s drawing being revealed," Thompson, founder of Brainbowinc, told Mashable. "I thought ("Draw Something" would)?be a good match for a song with a lot of nouns."

As Mashable noted, Brainbowinc has worked with Mayer's label Columbia Records before, but they weren't involved in his creating the video. Nor is Mayer the first artist to get the "Draw Something" treatment -- singer/songwriter Isaac Simons asked fans to contribute artwork from the game for his "Call to Arms" video in March. ?

Pest management and bug control Companies

Bug control services provide an invaluable service to their area. If you have ever had a good infestation of unwanted pests, then you will likely understand what a serious issue this can be and how important it is to get the situation rear under control. Pests range between things like rats (vermin) to things like roaches, and there are countless variations between -- all of while are generally highly problematic. Will probably like look at why it is so important to find nearby pest control and to get rid of any pests you may have as quickly and effectively as possible.

Pests can have a disastrous impact on the fitness of our family if not managed as they can multiply quickly and cause greatest damage. Pests like cockroaches, rats, reddish and black helpless ants, spiders, bed bugs, gold fish are some of the significant ones, which can invade our home and property. One of the main harmful effects of needing pests in your feel is that they carry bacteria and viruses, which usually give birth to numerous health-related problems. Moreover, several of these pests can cause serious harm to your property. Food products can be ruined by rats, flies as well as cockroaches while rats and termites might cause serious harm to your personal property.

Effective pest control may be the only solution to this menace of pests. Various pest-control agencies specialize in these products and companies, and they can provide their services rapidly without any hassles. Bug elimination company, or since some call it, "the exterminator" possess both the experience and the tools to identify the particular pest, and the way to obtain your infestation. By using their previous knowledge, as well as top of the line products, they have got the ability to return your household to normality from anywhere from a few hours or a week.

Pest Control Services have a very team of pros who can come to our location and access your situation and advise strategies by which they can eliminate these pests without having wasting much of our valuable time and money. They also take into account the health hazards that can be induced especially to kids during the course of pest-control services along with the means and methods where it can be prevented simply by proper guidance and precautions. Most of the pest-control providers use natural methods and pesticides, which can be tested and qualified, and hence they don't have dangerous effects around the user and are also environment-safe.

Nowadays, most of these providers have their own websites, so you can visit their websites and collect all the information that is required. You can check about the range of companies they offer, the techniques they will use and also get specifics of the experience and training course of people working generally there. Word of mouth is another great choice; ask your friends and also colleagues who have previous experience of taking these services. Since they have a firsthand experience of taking these services, their advice as well as opinion will be fairly beneficial for you. You may also read customer reviews along with testimonials, which will supply you a fairly good idea about the quality of such pest-control providers.

Keywords: pest control, pest control management, bug control, pest control companies

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Boost Mobile to Unveil New Unlimited BlackBerry Messenger (BBM ...

BlackBerry Curve 9310

Boost Mobile, a leader in the no-contract wireless industry with award-winning service plans, will introduce another industry first, BBM Unlimited, which features worldwide unlimited access to BlackBerry Messenger (BBM) and talk and text with payments that shrink to as low as $30 a month.? Continuing the Boost Mobile trend of offering more choice, flexibility and value, this offer is available beginning on July 10 exclusively with the BlackBerry Curve 9310 smartphone, which is launching the same day for $99.99 (excluding taxes).?

BBM, available for all BlackBerry users worldwide, is one of the largest mobile social networks with more than 56 million active customers globally. Customers can experience real-time communications and easily chat with friends at the speed of now, with instant responses and ?read? confirmations. Plus, BBM goes beyond chat with more than 1,000 BBM-connected apps available for download on BlackBerry App World. BBM-connected applications offer a social, interactive experience that?s not available on any other smartphone platform.

Similar to other monthly unlimited plans offered by Boost Mobile, the $45 BBM Unlimited plan provides customers the opportunity to be rewarded for simply making on-time payments. For every six on-time payments, customers will see their monthly payment shrink by $5, eventually getting down to as low as $30 a month for unlimited nationwide talk and text and worldwide BBM access. Payments do not need to be consecutive to qualify for these saving milestones.

BlackBerry Curve 9310 gives consumers the full power of the BlackBerry messaging and social-centric applications in the familiar BlackBerry Curve form factor. The smartphone will be available at Boost Mobile exclusive retail stores, select independent wireless dealer locations nationwide and at www.boostmobile.com with free shipping. It will also be available at select Best Buy locations next month.

Messaging on BlackBerry Curve 9310 is made easy with a full QWERTY keyboard and optical trackpad.? In addition to real-time chat with BBM, customers can share large multimedia files (up to 6MB), including pictures, voice notes, calendar entries and locations. The smartphone is also Wi-Fi enabled, giving users the opportunity to enjoy unlimited data. Key smartphone features include:

Dedicated BlackBerry Messenger key
Text and email (supports Yahoo!, Gmail and Hotmail)
3.2MP camera with flash
Speedy Web browsing
BlackBerry 7.1 OS
Access to thousands of apps and games on BlackBerry App World
Easy Access to Facebook, MySpace, Twitter, YouTube and more
Stereo Bluetooth support
Wi-Fi and GPS1 enabled
Built-in FM radio

Great battery life (up to eight hours talk time or 18 days standby; up to 70 hours of music playback with headphones)

Filed Under: BlackBerry ? Sprint

Tags: BlackBerry App World ? BlackBerry Curve 9310 ? BlackBerry Messenger ? Boost Mobile ? Cell Phone ? Cool Gadget ? latest gadget ? Mobile News ? mobile plan ? new release ? phone news ? Talk & Text ? Telecom news

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An Ethical Question ? creating an ethical environment | WOMEN ...

Since the early 1980?s, there has been increasing concern and discussion regarding business values, ethics and morals. Good ethical behaviour and strong values are prime company assets and important components for long term business success.

While large businesses identify specific behaviours as inappropriate or detrimental to achieving organizational objectives, many small business do not consider or have the resources to address the issue. ??That is beginning to change as many small businesses are recognizing the positive relationship between demonstrating strong and specific ethical values, and productivity and profitability.

So how does a small business owner foster an ethical environment?

Because everyone has a different idea of ?right? and ?wrong? based on familial values and past experiences, it is important to include employee?s opinions and thoughts about?business values. Open discussions can take place at staff meetings, planning sessions or round tables. Once these values have been established, it is important to recognize and adhere to them, especially by the owner or manager. Reinforcing these values during employee training is also essential.

A business owner can also give considerable weight to ethical behavior in relation to other business?activities. Business ethics (and ethics in general) is a soft and subjective topic (unlike, say, accounting, where rules, regulations and practices are strictly set in place).? Therefore, priority should be given to ethical practices, especially when they are new, so employee attention,?acceptance and practice?can take place.

Consistency also aids in the development of business ethics. To be consistent, values, beliefs and actions should be rational and free of contradictions. To uncover contradictions, examine situations where values were tested. Were situations handled?similarly? Were there exceptions? If so, how was the exception justified? In other words, we must apply the same standards to one situation that we apply to another unless we can prove that the two situations differ.

Achieving the desired values require time, effort, consistency, and support from all staff members. By hiring the right employees and continually providing recognition based on adherence and acceptance, organizational values become internalized. The challenge lies in establishing clear values and balancing the importance of ethics while increasing the bottom line. How balanced these two goals are will determine the success and satisfaction?of the owner and the employees, as well as customers.

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Exclusive: Amber Heard And Girlfriend Tasya Split

In the midst of Johnny Depp's public separation from Vanessa Paradis after 14 years together, his rumored new flame Amber Heard has parted ways with her significant other.

In Touch, on newsstands now, can exclusively reveal that the bisexual blonde, 26, has split from her girlfriend, artist/photographer, Tasya van Ree.

"They are no longer in a relationship,? an insider tells In Touch. The women have reportedly been together since 2008 and came out as a couple at GLAAD's 25th anniversary bash in LA. However, the insider reveals the two quietly split several months back, as things between Amber and Johnny began to heat up.

According to the insider, the duo remain friends and Tasya appears to be enjoying single life again. "[Tasya] was chatting and laughing with several beautiful women,? an eyewitness, who recently spotted her at LA's Bar Marmont, tells In Touch.

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Why Hire Professional Movers for Your Next Local or Long-Distance ...

Whether you?re moving down the street or across the country, moving can be stressful and frustrating. You have to go through your belongings and decide what?s going and what?s staying or being thrown out. You have to pack. And then there?s the small matter of actually moving everything from point A to point B. Unless you have a small army of friends and family or are literally only moving a few suitcases? worth of items, it?s worth it to consider hiring professional movers to do the heavy lifting. Your health, your belongings, and your friends and family will thank you.

Speed and Efficiency

Professional movers make a living packing boxes, carrying furniture, and loading vans. They may even do multiple local moves in a day. All of that experience means that they can look at your apartment or house and quickly see the best way to pack and arrange everything in the truck for optimum efficiency. Then, they can load and unload with ease. With the help of the pros, a move that would take you all day might be done in hours, leaving you with ample time to start unpacking and organizing on the other end.

Protecting Your Valuables

Do you know the best way to pad your antique dresser to protect it from scratches and dings? How should you secure fragile items in a moving truck or your car so they don?t fall over or crash into other items? How can you get your sofa down the stairs without damaging the furniture, walls, or banister? A professional relocation company can not only get the job done quickly, but also ensure that neither your possessions nor the spaces you?re leaving and entering sustain damage during the move. Your moving team will pack and wrap furniture and electronics carefully to keep them safe, and they?ll pack the truck so that nothing has the chance to slide around and break. Plus, you can purchase moving insurance-whereas if you break something yourself, it?s up to you to replace it.

Safety Considerations

Lifting and carrying heavy items during a move can lead to strained muscles if you aren?t used to doing that kind of manual labor and don?t know how to lift and carry safely. There?s also a chance you could injure yourself or someone else by dropping a heavy box or appliance, or by improperly securing something in the van or truck. Again, both long-distance and local movers are trained to take all necessary safety precautions when working with oversized items. Save yourself the struggle and the pain by trusting the heavy lifting to pros who know what they?re doing.

There are other benefits to hiring professional movers. Some companies offer packing services as well as moving services. Some movers will disassemble furniture at the move-out site and reassemble it upon arrival. Depending on your budget and the size of the move, you may want to take advantage of these additional services. After all, you?ve got enough on your plate with the organizing and unpacking alone. Why make a frustrating and exhausting experience harder? Bring in a moving company to lighten the load.

Aglaia Rara has moved cross-country twice, with the help of movers. She is a senior Internet marketing strategist with the SEO firm Prospect Genius.

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Location | Paris - Avant-Guardian Musings

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Wednesday, June 27, 2012

Cyprus: no figure yet on size of EU bailout sought

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AP source: Obama to make first campaign bus trip


	Essential News from The Associated Press

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Best Online Auction Web-sites and Web Design like a Business | 4u ...

Article by Edna Lorenzen

Best Online Auction Web-sites and Web Design like a Business ? Internet

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Finest Online Auction Marketplace Websites

If you?d like to enter a trade solutions on auction sites, it makes sense to discover the most effective web sites. There?s a chance you?re considering reducing it all the way down to the top 5 world wide web online auction marketplace web-sites. This allows you an enhancement without having to be too much to handle.

When you look for the most notable 5 world-wide-web online auction marketplace web sites, you will find that various resources provides you with various answers. What is still same is the ebay affiliate network is actually on top of their email list. Should you be looking for an internet site that most of us have read about, try out eBay. EBay gives a lot of useful details on the buyer and also the seller. The achievements of the vendor enhances the results of auction web sites, therefore they provide the home owner a number of methods to help them obtain a good price.

Bing! sales status is yet another web page that is certainly consisently inside number of top 5 world wide web online auction marketplace internet sites. The amazon online marketplace.org auctions, UBid.internet, and bida-ton.org are well thought of for traders.

Though it is critical to offer at the internet site its keep are a large number of purchasers, understand that level of competition is also a lot tougher at web sites like amazon. Look into the web sites to guarantee there?s a market for what you?re really marketing, then look at the competitiveness to your merchandise. Though craigslist and ebay might appear to trade anything, it doesn?t mean that anybody who directories an item there carries it or offers the price tag they want.

Read the 5 most beneficial world wide web auctions. Thin it to sales that are fitted with a niche for that you are providing. Find the web site that utilizes you, and then make money with auctions.

Web Design as being an Enterprise

Online just keeps growing. Organization know the benefits of becoming on the web, but try not to often discover how to design and style a superb web site. In case you have some creative imagination and know concepts about web design, you could be considering starting off a web design organization.

Starting up a web design customers are not a whole lot completely different from starting other businesses. Just discovering how to build a website seriously isn?t plenty of. You should do analysis to be assured you could have each of the equipment you will need. A laptop and printer are necessary. You would like images program and Html code editing and enhancing program. Recall you are being employed by enterprises, therefore you a little understanding of have no idea business site efficient.

It will help to a target a market current market. Find an area you might have generally acquired a passion for and create tips on that particular industry. Like this you may stand out as among the finest that individual arena.

For anyone who is just starting up your web design small business, you can study several of the rules by helping out to support another person organize a website or better their web site. Look at sites from local business owners and give them a call to offer the services you receive. Often the small enterprises have create their own personal web page without specialized help. They could delightful your abilities, and may eventually function as precious research.

When establishing your web design business enterprise, do remember that it is a business. Figure out how to placed your charges and make excellent files for income tax purposes.

When you contemplate starting off your web design business enterprise, you should definitely know what you should know ahead of offering the services you provide. Should you have creative imagination and an interest in building web sites, this may be a company for you personally.

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July 9, 2010 -- Blog Marketing for a New Online Business ? the Best Free Blog Websites and Posting Tips for You
June 26, 2012 -- Best online web design certificate programs with flexible schedules?
June 11, 2012 -- I want to put my grandpa?s stamps collection to online auction, what is the best philately auction web site?
June 10, 2012 -- Q&A: Anyone have info on a online business: Auction Listing by Elizabeth Jackson?
June 2, 2012 -- How do I build an online auction business?
June 1, 2012 -- what is the best pay per click advertising for a small business like mine. I am a chiropractor.?
May 31, 2012 -- What?s your understanding of an ?Online Silent Auction? & what?s the best computer program available for one?
May 25, 2012 -- Q&A: What are some non-scam websites that help newbies start an online, stay-at-home business?
May 9, 2012 -- what are other FREE online auction sites like ebay?
May 8, 2012 -- How to Start an Online Auction Business

Tags: Auction, Best, Business, design, like, online., Websites

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Tuesday, June 26, 2012

Queen of Sheba left genetic legacy to Ethiopians, study finds

Ethiopians's long-ago genetic mixing with populations from Israel and Egypt is a legacy of the Queen of Sheba and her companions, say researchers.?

By Stephanie Pappas,?LiveScience / June 21, 2012

A depiction of the Queen of Sheba meeting King Solomon of Israel from the Florence Baptistry in Italy.

Richardfabi, distributed under a Creative Commons license by Wikimedia.

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The Queen of Sheba's genetic legacy may live on in Ethiopia, according to new research that finds evidence of long-ago genetic mixing between Ethiopian populations and Syrian and Israeli people.

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The Queen of Sheba, known in Ethiopia as Makeda, is mentioned in both the Bible and the Quran. The Bible discusses diplomatic relations between this monarch and?King Solomon of Israel, but Ethiopian tradition holds that their relationship went deeper: Makeda's son, Menelik I, the first emperor of Ethiopia, is said to be Solomon's offspring.

Whether this tale is true or not, new evidence reveals close links between Ethiopia and groups outside of Africa. Some Ethiopians have 40-50 percent of their genomes that match more closely with populations outside of Africa than those within, while the rest of the genomes more closely match African populations, said study researcher Toomas Kivisild of the University of Cambridge. [History's Most Overlooked Mysteries]

"We calculated genetic distances and found that these non-African regions of the genome are closest to the populations in Egypt, Israel and Syria," Kivislid said in a statement.

From its perch on the Horn of Africa, Ethiopia is the site of early hominin discoveries such as "Lucy," a fossilizedAustralopithecus afarensis?and an early human ancestor. Ethiopia is also a?gateway between Africa and Asia, according to Kivislid and his colleagues. But few genetic studies have delved specifically into the Ethiopian genome.

Both agriculture and linguistics show a link between Ethiopia and lands outside of Africa. For example, archaeologists have uncovered wheat and barley farming in Ethiopia, agriculture that first arose in the Fertile Crescent of the Middle East. Linguistically, Ethio-Semitic, a language spoken both in Ethiopia and nearby Eritrea, has been traced to a Middle Eastern origin.?

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Matt Kenseth to leave Roush at end of season

FILE - This May 27, 2010 file photo shows Matt Kenseth before qualifying for the NASCAR Sprint Cup Series Coca-Cola 600 auto race at Charlotte Motor Speedway in Concord, N.C. NASCAR points leader Kenseth is leaving Roush Fenway Racing at the end of the season, and Ricky Stenhouse Jr. will be promoted to his seat in the Sprint Cup Series. Kenseth has won 22 Cup races, including two Daytona 500s and the 2003 championship, driving for Jack Roush. He's been in the No. 17 Ford his entire career. (AP Photo/Chuck Burton, File)

FILE - This Feb. 28, 2012 file photo shows Matt Kenseth, left, and car owner Jack Roush celebrating in victory lane after Kenseth won the NASCAR Daytona 500 auto race at Daytona International Speedway in Daytona Beach, Fla. NASCAR points leader Kenseth is leaving Roush Fenway Racing at the end of the season, and Ricky Stenhouse Jr. will be promoted to his seat in the Sprint Cup Series. (AP Photo/Terry Renna, File)

FILE - This April 13, 2012 file photo shows Matt Kenseth listens to a crew member while sitting in his car during practice for the NASCAR Sprint Cup auto race at Texas Motor Speedway, in Fort Worth, Texas. NASCAR points leader Kenseth is leaving Roush Fenway Racing at the end of the season, and Ricky Stenhouse Jr. will be promoted to his seat in the Sprint Cup Series. (AP Photo/Larry Papke, File)

CHARLOTTE, N.C. (AP) ? NASCAR points leader Matt Kenseth, one of the longest-tenured drivers in the series, is leaving Roush Fenway Racing at the end of the season.

He will be replaced in the No. 17 Ford ? the car he has driven for all but one of his 452 career starts ? by Nationwide Series champion Ricky Stenhouse Jr. and Kenseth's long relationship with Ford will apparently come to an end. He is believed to be headed to Joe Gibbs Racing, either in Joey Logano's No. 20 Toyota or a fourth unannounced team.

Why? Good question. The team offered no answers in the sudden divorce of one of NASCAR's longest active relationships. Only Jeff Gordon, with Hendrick Motorsports since 1993, has been with his team longer than Kenseth has been with Jack Roush.

"I'd like to thank Matt Kenseth for his many years of loyal service," co-owner Roush said Tuesday. "Matt has been an integral part of this organization for well over a decade, and we are extremely appreciative of his accomplishments and contributions to the team, and will always consider him a part of the Roush Fenway family."

Kenseth and teammate Greg Biffle are ranked 1st and 2nd in the Sprint Cup Series, clearly poised to make a run at the championship. Kenseth opened the season with his second Daytona 500 victory, and has 11 top-10 finishes through 16 races.

Kenseth did not respond to a request for comment on Tuesday, but tweeted about his departure.

"I'm very thankful to Jack Roush for the opportunities he's given me over the past 14 years. Together we have enjoyed a lot of success," he posted. "And as a team we are committed as ever to the remainder of the 2012 season and chasing a 3rd sprint cup title for Jack and RFR."

With Roush, Kenseth has built a career worthy of Hall of Fame consideration. Besides the wins at Daytona, he has won 22 Cup races overall, and the 2003 championship. In the Nationwide Series, Kenseth has won 26 races driving for Roush.

His relationship with current general manager Robbie Reiser, like Kenseth a native of Wisconsin, dates at least to 1997, when Kenseth first drove Reiser's No. 17 entry. It was eventually merged into the Roush organization, and Reiser became Kenseth's crew chief at Roush in 2000, Kenseth's rookie season.

"Matt and I broke into this sport together, learned the ropes and were able to bring home a championship," Reiser said. "Over the 20 years we have worked with each other, Matt has been a fierce competitor and become a close friend, not only for me, but as a mentor to young drivers like Ricky. I wish Matt nothing but the best for the next phase of his career, and know that we'll remain close."

There was speculation last weekend at Sonoma that Kenseth was leaving to join JGR, which is in a contract year with Logano. The team also has room to expand to a fourth car, and it is possible Gibbs officials are trying to move Kenseth in and keep Logano at the same time.

Team president J.D. Gibbs did not respond to a request for a comment Tuesday, and said at Sonoma he could not talk about Kenseth.

Jamie Allison, director of Ford Racing, said the blue oval brand is was disappointed Kenseth is leaving.

"He will be certainly missed by us and the Ford Racing fans," Allison said. "We are thankful for Matt's winning efforts and championship-caliber success with the Roush and Ford racing programs these past 16 years, both on and off the track. We will focus on this year and look forward to more success on the track in his No. 17 Ford Fusion this season."

Kenseth's car has had sponsorship woes the last few years, and Roush is funding a large portion of this year's schedule himself for the 40-year-old Kenseth. The organization dropped David Ragan and its fourth team because of a lack of sponsorship at the end of last season, and also ponied up significant money to re-sign Carl Edwards last season. Roush also signed Biffle to a contract extension last season.

The team desperately needs a slot for the 24-year-old Stenhouse, who is locked into a long-term contract but has nowhere to go in Roush's Cup lineup. The organization has a similar problem with 2011 Daytona 500 winner Trevor Bayne, who is also in a long-term contract and had his Nationwide Series team shuttered earlier this season because of no funding.

Stenhouse will be far cheaper than Kenseth in terms of salary, and he is much younger and clearly has a future with the organization.

"We feel that he is not only a key piece of our team's future, but a key piece of the future of the sport," Roush said of Stenhouse. "Roush Fenway is an organization with a wonderful past and present, as well as an extremely promising future, and I can't think of a better candidate than Ricky to usher in the next era of success for the team."

It's unusual, though, for a team and driver to decide to part ways during a championship run. Roush technically has three shots at the Sprint Cup title, as Biffle has proven to be just as strong as Kenseth this season. And Edwards, who tied Tony Stewart last year for the championship but lost the title on a tie-breaker, could still qualify for the 12-driver Chase for the Sprint Cup championship field.

Roush, meanwhile, doesn't think Kenseth's departure will hurt the No. 17 team's championship hopes.

"The No. 17 is positioned extremely well this season, and I'm committed to providing the team the best resources to continue their run for the 2012 championship," he said. "I have no doubt that Matt will do his part."

Associated Press

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Teacher, 4 students held over alleged hazing

By NBC Los Angeles and news services

FONTANA, Calif. -- A Southern California high school teacher was arrested on suspicion of directing students to assault at least one other student in a classroom hazing incident, police said Sunday.

Emmanuel Delarosa, 27, along with four students were arrested Saturday after a student who said he was a victim of the hazing contacted school police, Fontana police Sgt. Robert Morris said.

Investigators alleged that Delarosa, a summer school teacher at A.B. Miller High School, knew about the hazing ? and in at least one instance directed some students to carry out the hazing to curb behavior problems in the classroom, Morris said.

Police: High school cheerleaders suspended for hazing incident in Utah

He declined to describe the nature of the hazing, citing the ongoing investigation.

At least one student suffered minor injuries, Morris said.

NBC Los Angeles reported that several students has been interviewed by?detectives.

Jail records show that an 18-year-old student arrested in the case faces charges of assault, child cruelty and attempted sodomy. Fernando Manuel Salgado was being held in lieu of $100,000 bail.

5 found duct-taped: Boston University students under investigation

The names of the other three male students were not released because they are minors. Police said they were arrested for investigation of assault and child endangerment.

Delarosa was booked for investigation of child endangerment and released on bail.

The Associated Press and NBC Los Angeles contributed to this report.

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Significant sea-level rise in a two-degree warming world

ScienceDaily (June 24, 2012) ? Sea levels around the world can be expected to rise by several metres in coming centuries, if global warming carries on. Even if global warming is limited to 2 degrees Celsius, global-mean sea level could continue to rise, reaching between 1.5 and 4 metres above present-day levels by the year 2300, with the best estimate being at 2.7 metres, according to a study just published in Nature Climate Change. However, emissions reductions that allow warming to drop below 1.5 degrees Celsius could limit the rise strongly.

The study is the first to give a comprehensive projection for this long perspective, based on observed sea-level rise over the past millennium, as well as on scenarios for future greenhouse-gas emissions.

"Sea-level rise is a hard to quantify, yet critical risk of climate change," says Michiel Schaeffer of Climate Analytics and Wageningen University, lead author of the study. "Due to the long time it takes for the world's ice and water masses to react to global warming, our emissions today determine sea levels for centuries to come."

Limiting global warming could considerably reduce sea-level rise

While the findings suggest that even at relatively low levels of global warming the world will have to face significant sea-level rise, the study also demonstrates the benefits of reducing greenhouse-gas emissions. Limiting global warming to below 1.5 degrees Celsius and subsequent temperature reductions could halve sea-level rise by 2300, compared to a 2-degree scenario. If temperatures are allowed to rise by 3 degrees, the expected sea-level rise could range between 2 and 5 metres, with the best estimate being at 3.5 metres.

The potential impacts are significant. "As an example, for New York City it has been shown that one metre of sea level rise could raise the frequency of severe flooding from once per century to once every three years," says Stefan Rahmstorf of the Potsdam Institute for Climate Impact Research, co-author of the study. Also, low lying deltaic countries like Bangladesh and many small island states are likely to be severely affected.

Sea-level rise rate defines the time for adaptation

The scientists further assessed the rate of sea-level rise. The warmer the climate gets, the faster the sea level climbs. "Coastal communities have less time to adapt if sea-levels rise faster," Rahmstorf says

"In our projections, a constant level of 2-degree warming will sustain rates of sea-level rise twice as high as observed today, until well after 2300," adds Schaeffer, "but much deeper emission reductions seem able to achieve a strong slow-down, or even a stabilization of sea level over that time frame."

Building on data from the past

Previous multi-century projections of sea-level rise reviewed by the Intergovernmental Panel on Climate Change (IPCC) were limited to the rise caused by thermal expansion of the ocean water as it heats up, which the IPCC found could reach up to a metre by 2300. However, this estimate did not include the potentially larger effect of melting ice, and research exploring this effect has considerably advanced in the last few years. The new study is using a complementary approach, called semi-empirical, that is based on using the connection between observed temperature and sea level during past centuries in order to estimate sea-level rise for scenarios of future global warming.

"Of course it remains open how far the close link between temperature and global sea level found for the past will carry on into the future," says Rahmstorf. "Despite the uncertainty we still have about future sea level, from a risk perspective our approach provides at least plausible, and relevant, estimates."

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The above story is reprinted from materials provided by Potsdam Institute for Climate Impact Research (PIK).

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

Journal Reference:

Schaeffer, M., Hare, W., Rahmstorf, S., Vermeer, M. Long-term sea-level rise implied by 1.5? C and 2? C warming levels. Nature Climate Change, 2012 DOI: 10.1038/NCLIMATE158

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

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Monday, June 25, 2012

7 pharmaceutical companies join academic researchers to speed TB drug discovery

Public release date: 25-Jun-2012
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Contact: Daniel Pawson
dpawson@globalhealthstrategies.com
718-873-3169
Global Health Strategies

Groundbreaking partnership seeks rapid cure to reduce treatment time from 6 months to 1 month

Seven pharmaceutical companies and four research institutions, working with the Bill & Melinda Gates Foundation, have launched a groundbreaking partnership that aims to speed the discovery of essential new treatments for tuberculosis (TB).

The partnership, known as the TB Drug Accelerator (TBDA), will target the discovery of new TB drugs by collaborating on early-stage research. The long-term goal of the TBDA is to create a TB drug regimen that cures patients in only one month. Existing drugs, all at least 50 years old, require six months to cure the disease a lengthy process that contributes to 20-30% of patients dropping out before completion.

Aided by nearly $20 million from the Gates Foundation, partners officially launched the TBDA in April and have begun the first round of screening for new TB drug candidates. The TBDA aims to develop five new preclinical drug candidates with treatment-shortening potential within 5 years and proof-of-concept for a one-month three-drug regimen within 10 years.

"The TB Drug Accelerator establishes a new paradigm of cooperation in drug discovery," said Sanofi Chief Executive Officer Chris Viehbacher, speaking on behalf of the pharmaceutical industry partners. "By working together on this, we can optimize our research and speed the development of one of the most pressing needs in global health."

Through this partnership, the participating pharmaceutical companies -- Abbott, AstraZeneca, Bayer, Eli Lilly, GlaxoSmithKline, Merck and Sanofi will open up targeted sections of their compound libraries and share data with each other and four research institutions: the Infectious Disease Research Institute; the National Institute of Allergy and Infectious Diseases, part of the U.S. National Institutes of Health; Texas A&M University; and Weill Cornell Medical College. Breaking from traditional research and development practices, the companies will work together to develop the best prospects, regardless of where the drug originated. The structures of lead compounds identified through the program will ultimately be placed in the public domain.

"TB drug discovery has reached a crossroads," said Dr. Carl Nathan, Professor and Chairman of the Department of Microbiology and Immunology at Weill Cornell Medical College. "Finding new and faster-acting TB drugs will take a new kind of partnership, connecting not only academia and industry, but drug company with drug company. The TB Drug Accelerator is a historic experiment in innovative collaboration."

Tuberculosis is a bacterial infection that attacks the respiratory system and other organs. It is the second leading infectious cause of death worldwide, having killed nearly 1.4 million people in 2010 alone. At any given moment, more than 12 million people around the world are suffering from active TB.

The high percentage of patients who fail to complete the current six-month treatment regimen adds significantly to the TB burden. High default rates lead to increased mortality, contribute to TB drug resistance and allow patients to continue to infect others. Shortening treatment regimens to even two months would keep an additional one million people on treatment each year.

"Innovative partnerships are critical to helping us solve the most pressing challenges of global health," said Trevor Mundel, president of the Global Health Program at the Bill & Melinda Gates Foundation. "It's our hope that the TB Drug Accelerator will set a precedent for drug discovery and serve as a resource for others."

The TBDA will add to existing collaborative efforts on TB, building a more robust drug discovery pipeline to complement other initiatives, such as Critical Pathways to TB Drug Regimens (CPTR), which works with the Global Alliance for TB Drug Development to speed the clinical development of new combination TB drug therapies.

###

Media contacts for partners follow:

Abbott: Colin McBean, +1 847 938 3083, colin.mcbean@abbott.com
AstraZeneca: Andrea Conners, +1 610 620 5675, andrea.conners@astrazeneca.com
Bayer HealthCare AG: Kerstin Crusius, +49 (0)30 468 14726, kerstin.crusius@bayer.com
Bill & Melinda Gates Foundation: +1 206 709 3400, media@gatesfoundation.org
Eli Lilly: David Marbaugh, +1 317 277 5620, marbaugh_david_j@lilly.com
GlaxoSmithKline: David Daley, +44 (0)20 8047 2615, david.t.daley@gsk.com
Infectious Disease Research Institute: Tanya Parish, +1 206 330 2525, tanya.parish@idri.org
Merck & Co.: Kelley Dougherty, +1 908 423 4291, kelley.dougherty@merck.com
National Institute of Allergy and Infectious Diseases: Kathy Stover, +1 301 451 2278, kathy.stover@nih.gov
Sanofi: Jean-Marc Podvin, +33 (0) 6 7457 5170, jean-marc.podvin@sanofi.com
Texas A&M University: Tom Hughes, +1 979 862 4001, tomhughes@tamu.edu
Weill Cornell Medical College: Lauren Woods, +1 212 821 0579, law2014@med.cornell.edu

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7 pharmaceutical companies join academic researchers to speed TB drug discovery

Public release date: 25-Jun-2012
[ | E-mail |

Share ]

Contact: Daniel Pawson
dpawson@globalhealthstrategies.com
718-873-3169
Global Health Strategies

Groundbreaking partnership seeks rapid cure to reduce treatment time from 6 months to 1 month

###

Media contacts for partners follow:

Abbott: Colin McBean, +1 847 938 3083, colin.mcbean@abbott.com
AstraZeneca: Andrea Conners, +1 610 620 5675, andrea.conners@astrazeneca.com
Bayer HealthCare AG: Kerstin Crusius, +49 (0)30 468 14726, kerstin.crusius@bayer.com
Bill & Melinda Gates Foundation: +1 206 709 3400, media@gatesfoundation.org
Eli Lilly: David Marbaugh, +1 317 277 5620, marbaugh_david_j@lilly.com
GlaxoSmithKline: David Daley, +44 (0)20 8047 2615, david.t.daley@gsk.com
Infectious Disease Research Institute: Tanya Parish, +1 206 330 2525, tanya.parish@idri.org
Merck & Co.: Kelley Dougherty, +1 908 423 4291, kelley.dougherty@merck.com
National Institute of Allergy and Infectious Diseases: Kathy Stover, +1 301 451 2278, kathy.stover@nih.gov
Sanofi: Jean-Marc Podvin, +33 (0) 6 7457 5170, jean-marc.podvin@sanofi.com
Texas A&M University: Tom Hughes, +1 979 862 4001, tomhughes@tamu.edu
Weill Cornell Medical College: Lauren Woods, +1 212 821 0579, law2014@med.cornell.edu

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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FDA probes safety issues with metal hip implants

WASHINGTON (AP) ? Metal hip replacements implanted in a half-million Americans may be failing earlier than expected, but it could be years before U.S. health regulators have a clear picture of the scope of the problem.

The Food and Drug Administration holds a two-day meeting starting Wednesday to scrutinize the safety of metal-on-metal hip implants, following years of patient reports of pain and swelling that sometimes requires removal of the devices. It is a challenging, but familiar, predicament for the FDA: reviewing the safety of a device that was expected to be superior, but which may actually be more dangerous than what came before.

For decades nearly all orthopedic implants were made from plastic or ceramic. But in the last 10 years some surgeons began to favor implants made with metal stems and sockets. Laboratory tests suggested the devices would be more resistant to wear and reduce the chances of dislocation.

But recent data gathered by surgeons in the U.K. appears to show just the opposite.

In March, British experts at the world's largest artificial joint registry told doctors to stop using metal-on-metal hip replacements, citing an analysis showing they have to be replaced more often than other implants. Hip replacements are supposed to last between 10 to 15 years, but more than 6 percent of patients with metal hips needed them replaced after less than five years. That compared with just 2 percent of people who had ceramic or plastic joints. Both types of devices are prescribed for people suffering hip pain and limited movement due to arthritis or injury.

British regulators now recommend that people who have the implants get yearly blood tests to make sure no dangerous metals are seeping into their bodies as the components rub against each other.

U.S. regulators have not made any similar recommendations for the estimated 500,000 American patients who have received the devices.

FDA scientists say they want to consider all available information before making their recommendations ? not just the data from the U.K.

"Why look at a single registry when there's data from around the world?" said Dr. William Maisel, FDA's chief scientist for medical devices, in an interview with the Associated Press. "This is an opportunity for us to look at all the available information so that we can have a thoughtful conversation about what clinical recommendations can be made."

Maisel said the FDA is working to combine data from foreign countries and the U.S. to determine which groups of patients and implants are most problematic. On Wednesday and Thursday the FDA will ask a panel of experts to recommend the best practices for monitoring patients with the devices. Panelists will consider blood tests, medical imaging and laboratory tests.

But some U.S. orthopedic specialists say they have already reached their own conclusions about metal hips.

"In my personal opinion there is very little room, if any, for metal-on-metal implants because the alternatives we have on the market are likely safer and as effective," said Dr. Art Sedrakyan, professor of public health at Weill Cornell Medical College in New York.

The FDA's deliberative approach to tackling the hip implant issue is in some ways a necessity. Unlike other countries, the U.S. has no national registry to track the performance of implants over time.

The FDA has received 16,800 event reports about metal hips between 2000 and 2011, but regulators stress that number is not very useful. Many doctors do not report problems to the FDA, and the volume of reports is influenced by news reports on safety issues.

A registry set up by Minnesota's HealthEast Care System recorded four times as many replacement surgeries for patients with metal-on-metal hips as those with other implant types. However, a similar registry set up by health care provider Kaiser Permanente found no difference between the two groups.

With little definitive data on U.S. hip implants, the agency has asked manufacturers like Johnson & Johnson, Zimmer Holdings Inc. and Biomet Inc. to conduct long-term, follow-up studies of more than 100 metal-on-metal hips on the U.S. market.

FDA scientists say the studies will help "fill in the blanks" on a number of scientific questions, including the effects of metal particles that often seep into the bloodstream as the implants wear down.

But Sedrakyan and others say it could be a decade or more before that information is available. In a commentary published last week in the New England Journal of Medicine, Sedrakyan and two co-authors pointed out those studies must run at least eight years to return the information FDA is seeking. Based on the authors' analysis of FDA records, the FDA has reached agreements on the design of less than 25 percent of the studies, and it's unclear whether any of the studies have actually begun. The FDA notified the companies last May.

The prospect of safety findings arriving in eight or 10 years is little comfort to patients like Mary Weaver, 48, who had both hips replaced with a metal implant from Johnson & Johnson in 2007 and 2008. J&J recalled the ASR hip replacement in 2010, after reports that it was failing in some patients after only a few years after implantation.

Due to increasing pain and elevated metal levels in her blood, Weaver had both implants removed in 2011. She was let go from her job due to the time needed to undergo both surgeries, and is currently unemployed.

"I hope that no one has to go through this ? it's frustrating, it's emotionally draining," said Weaver, who lives in Mt. Jackson, Va. "It's not just hard on you, it's hard on your whole family because your quality of life is not what it used to be."

Like 90 percent of medical devices sold in the U.S., most metal-on-metal hips were approved via the FDA's fast track program for medical devices. Under the so-called 510k system, the agency waives clinical testing requirements for devices which appear similar to others already in use. Since plastic and ceramic hip replacements had been on the market since the 1950s, most metal hip replacements were approved without new clinical testing.

"I am so furious they would use my wife as a lab rat, along with the other 500,000 people who don't have a clue what is happening," said Dwight Schrag, 69, of Bellevue, Wash. Schrag's wife Mary received J&J's ASR hip in 2006 and had it removed due to pain and other side effects in 2010. Schrag is one of a number of public speakers who have signed up to speak at the FDA meeting.

It's not the first time the FDA's fast-track program for clearing devices has come under fire.

Last summer the Institute of Medicine said in a report that the FDA should abandon the 35-year-old system because it provides little assurance that the implants are actually safe. The Institute is composed of medical experts who advise the federal government.

Although the FDA itself requested the report from the Institute, agency officials rejected the group's conclusions, saying the 510k system works well for the vast majority of devices.

Associated Press

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Groundbreaking partnership seeks rapid cure to reduce treatment time from 6 months to 1 month

Groundbreaking partnership seeks rapid cure to reduce treatment time from 6 months to 1 month